Benefit：SR9011 suppressed the expression of BMAL1 messenger RNA in HepG2 cells in a REV-ERB-a/b-dependent manner. Moreover, SR9011 inhibited the activity of the SCNclock, with reversible inhibition of circadian oscillations.
The C-terminal of sr9011 family proteins lacks a ligand binding domain, but the expression of Rev Erb protein can be inhibited by recruiting nuclear receptor inhibitors and histone deacetylase 3. Histone deacetylase 3 is a rev Erb agonist and a small molecular chemical probe. Fon Taine et al. First reported that sr9011 has a correlation with inflammation, sr9011 can inhibit the expression of TR4, thus controlling the inflammatory signal. Foreign scholars have found that in human macrophages, the increase of sr9011 mRNA expression by pharmacological methods directly leads to the decrease of pro-inflammatory factor IL-6 mRNA expression.

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